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    A Rare Case of Prostate-Specific Antigen–Producing Metastatic Parotid Adenocarcinoma Developing Androgen Receptor Resistance

    Mayo Clinic Proceedings: Innovations, Quality & Outcomes
    Vol. 4Issue 5p601–607Published online: August 19, 2020
    • Jack R. Andrews
    • Mohamed E. Ahmed
    • Giovanni Motterle
    • Sam T. Albadri
    • Rimki Haloi
    • R. Jeffrey Karnes
    • and others
    Cited in Scopus: 0
      A 62-year-old man presented with a rising serum concentration of prostate-specific antigen (PSA) to 53.3 ng/mL (to convert to μg/L, multiply by 1) and a PSA doubling time of 2.6 months. Computed tomography, fluorodeoxyglucose–positron emission tomography, and C-11 choline positron emission tomography demonstrated a parotid mass with innumerable lytic bone lesions and diffuse metastatic disease to the neck and mediastinal lymph nodes. Mediastinal lymph node biopsy revealed salivary ductal adenocarcinoma that produced PSA and demonstrated androgen receptor sensitivity.
      A Rare Case of Prostate-Specific Antigen–Producing Metastatic Parotid Adenocarcinoma Developing Androgen Receptor Resistance

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