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    Rebound Vertebral Fractures in a Patient With Lung Cancer After Oncology-Dose Denosumab Discontinuation: A Cautionary Tale

    Mayo Clinic Proceedings: Innovations, Quality & Outcomes
    Vol. 3Issue 2p235–237Published in issue: June, 2019
    • Alexander Tyan
    • Sandip Pravin Patel
    • Shanna Block
    • Tudor Hughes
    • Karen C. McCowen
    Cited in Scopus: 0
      We describe a 55-year-old woman with lung cancer complicated by bone metastases. Treatment with denosumab (120 mg monthly) was interrupted after 9 doses because of concern for potential osteonecrosis of the jaw during upcoming dental work. Fifteen months after receiving the last dose of denosumab, the patient presented with 7 atraumatic spinal compression fractures requiring kyphoplasty for symptom relief. No malignancy was found in pathology specimens. Evaluation for secondary causes of osteoporosis was negative.
      Rebound Vertebral Fractures in a Patient With Lung Cancer After Oncology-Dose Denosumab Discontinuation: A Cautionary Tale

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